Metabolic pathways inhibitors can affect the therapeutic efficiency of doxorubicin
نویسندگان
چکیده
Cancers are a group of diseases characterized by uncontrolled growth and the spread abnormal cells . Colon cancer (CC) is one most aggressive tumor that leading to death in world In this study, an attempt was made evaluate effect different combinations 2-deoxy-d-glucose, metformin, doxorubicin on colon viability. Results revealed significant decrease viability after treatment with (2-DG- 2-DG – Dox , 2-DG- metformin - Dox) at certain concentrations.
منابع مشابه
assessment of the efficiency of s.p.g.c refineries using network dea
data envelopment analysis (dea) is a powerful tool for measuring relative efficiency of organizational units referred to as decision making units (dmus). in most cases dmus have network structures with internal linking activities. traditional dea models, however, consider dmus as black boxes with no regard to their linking activities and therefore do not provide decision makers with the reasons...
Examining the difficulty pathways of can-do statements from a localized version of the CEFR
The Japanese adaptation of the Common European Framework of Reference (CEFR-J) is a tailored version of the Common European Framework of Reference (CEFR), designed to better meet the needs of Japanese learners of English. The CEFR-J, like the CEFR, uses illustrative descriptors known as can-do statements, that describe achievement goals for five skills (listening, reading, spoken ...
متن کاملApoptosis: from Signalling Pathways to Therapeutic Tools
Apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. It is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal DNA fragmentation. Although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...
متن کاملThe endocytic pathway and therapeutic efficiency of doxorubicin conjugated cholesterol-derived polymers.
Previously synthesized poly(methacrylic acid-co-cholesteryl methacrylate) P(MAA-co-CMA) copolymers were examined as potential drug delivery vehicles. P(MAA-co-CMA) copolymers were fluorescently labelled and imaged in SHEP and HepG2 cells. To understand their cell internalization pathway endocytic inhibition studies were conducted. It was concluded that P(MAA-co-CMA) are taken up by the cells vi...
متن کاملNursery Seed Efficiency Can Affect Gains from Tree Improvement
The efficiency of a tree improvement program can be greatly affected by the degree of seed efficiency in the nursery. The gains from tree improvement can be 50% greater from a nursery with 90% seed efficiency than from a nursery with 60% seed efficiency. However, because the nursery and tree improvement are usually operated by different divisions, the goals of the nursery manager may not includ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Health Sciences (IJHS)
سال: 2022
ISSN: ['2550-6978', '2550-696X']
DOI: https://doi.org/10.53730/ijhs.v6ns2.7375